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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Phenethyl isothiocyanate, Irinotecan
Phytochemical Name Phenethyl isothiocyanate (PubChem CID: 16741 )
Anticancer drug Name Irinotecan (PubChem CID: 60838 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 949
Pair Name Phenethyl isothiocyanate, Irinotecan
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress
Gene Regulation Up-regulation Expression BAD hsa572
Up-regulation Expression BAK1 hsa578
Down-regulation Expression BCL2 hsa596
Up-regulation Phosphorylation CAMK2G hsa818
Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP8 hsa841
Up-regulation Expression CASP9 hsa842
Up-regulation Expression CYCS hsa54205
Up-regulation Phosphorylation EIF2AK3 hsa9451
Up-regulation Expression EIF2S1 hsa1965
Up-regulation Expression FAS hsa355
Up-regulation Expression HSPA5 hsa3309
Up-regulation Expression PARP1 hsa142
Down-regulation Expression XIAP hsa331
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
Result PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.
03. Reference
No. Title Href
1 Phenethyl isothiocyanate and irinotecan synergistically induce cell apoptosis in colon cancer HCT 116 cells in vitro. Environ Toxicol. 2024 Jan;39(1):457-469. doi: 10.1002/tox.23993. Click
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