Pair Name	Phenethyl isothiocyanate, Irinotecan
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAK1	hsa578
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Phosphorylation	CAMK2G	hsa818
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Phosphorylation	EIF2AK3	hsa9451
	Up-regulation	Expression	EIF2S1	hsa1965
	Up-regulation	Expression	FAS	hsa355
	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.